10 Most insane .22 LR Ammo for Self-Defense in 2025

Think the .22LR is just a plinking round? Think again. This tiny cartridge has been underestimated for years, but when loaded with the right ammo, it becomes a deadly force in self-defense situations. Speed, penetration, and terminal ballistics all come into play—making some of these rounds absolute game-changers.

In today’s countdown, we’re revealing the Top 10 Most Lethal .22LR Ammo for Self-Defense in 2025—from high-velocity hollow points to devastating segmented rounds. Some of these rounds can rival much larger calibers in stopping power, and trust me, you don’t want to miss #1 on this list!

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we’re breaking down the most lethal .22LR ammo choices for self-defense.

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